Inducible nitric oxide synthase inhibitor 1400W increases Na⁺,K⁺-ATPase levels and activity and ameliorates mitochondrial dysfunction in Ctns null kidney proximal tubular epithelial cells

• Main Authors: Sumayao, Rodolfo, Newsholme, Philip, McMorrow, Tara
• Format: text
• Published: Animo Repository 2018
• Subjects: Nitric-oxide synthase; Nitric-oxide synthase—Inhibitors; Oxidative stress; Epithelial cells; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/3509
• Institution: De La Salle University

Nitric oxide (NO) has been shown to play an important role in renal physiology and pathophysiology partly through its influence on various transport systems in the kidney proximal tubule. The role of NO in kidney dysfunction associated with lysosomal storage disorder, cystinosis, is largely unknown....