Fundamental study of detection of muscle hypertrophy-oriented gene doping by myostatin knock down using RNA interference

• Main Authors: Takemasa, Tohru, Yakushiji, Naohisha, Kikuchi, Dale Manjiro, Deocaris, Custer C., Widodo, Machida, Masanao, Kiyosawa, Hidenori
• Format: text
• Published: Animo Repository 2012
• Subjects: Muscles—Hypertrophy; RNA interference; Doping in sports; Biochemistry, Biophysics, and Structural Biology; Biology
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/5481
• Institution: De La Salle University

To investigate the feasibility of developing a method for detection of gene doping in power-athletes, we devised an experimental model system. Myostatin is a potent negative regulator of skeletal muscle development and growth, and myostatin-knockout mice exhibit a double-muscle phenotype. To achieve...