Glycerol stimulates innate chaperoning, proteasomal and stress-resistance functions: Implications for geronto-manipulation

• Main Authors: Deocaris, Custer C., Takano, Syuichi, Priyandoko, Didik, Kaul, Zeenia, Yaguchi, Tomoko, Kraft, David C., Yamasaki, Kazuhiko, Kaul, Sunil C., Wadhwa, Renu
• Format: text
• Published: Animo Repository 2008
• Subjects: Glycerin; Molecular chaperones; Stress (Physiology); Gerontology; Protein folding; Homeostasis; Biochemistry, Biophysics, and Structural Biology; Biology
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/5468
• Institution: De La Salle University

Aging is associated with accumulation of toxic intracellular and extracellular protein aggregates. Cells manage “aged” proteins by mobilizing their molecular chaperones or heat shock proteins that are also considered as determinants of lifespan in diverse species. In this study, we tested whether an...