Geoprotection by glycerol: Insights to its mechanisms and critical potentials
Chaperones, particularly the heat-shock proteins, are considered as key players in the maintenance of protein homeostasis and are associated with longevity and cellular immortalization. In this study, we investigated the geroprotective activity of the chemical chaperone glycerol. Glycerol showed sig...
Saved in:
Main Authors: | , , , , , |
---|---|
Format: | text |
Published: |
Animo Repository
2006
|
Subjects: | |
Online Access: | https://animorepository.dlsu.edu.ph/faculty_research/5466 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | De La Salle University |
id |
oai:animorepository.dlsu.edu.ph:faculty_research-6252 |
---|---|
record_format |
eprints |
spelling |
oai:animorepository.dlsu.edu.ph:faculty_research-62522022-04-20T03:49:16Z Geoprotection by glycerol: Insights to its mechanisms and critical potentials Deocaris, Custer C. Shrestha, Bhupal G. Kraft, David C. Yamasaki, Kazuhiko Rattan, Suresh I. S. Wadhwa, Renu Chaperones, particularly the heat-shock proteins, are considered as key players in the maintenance of protein homeostasis and are associated with longevity and cellular immortalization. In this study, we investigated the geroprotective activity of the chemical chaperone glycerol. Glycerol showed significant chaperoning activity in refolding heat-denatured luciferase in vivo and in protecting cells from heat stress-induced cytotoxicity. This was accompanied by decrease in p53, an upregulation of a stress chaperone mortalin/mtHsp70, and an increase in proteasome activity in the presence of oxidative stress. 2006-01-01T08:00:00Z text https://animorepository.dlsu.edu.ph/faculty_research/5466 Faculty Research Work Animo Repository Glycerin Molecular chaperones Aging—Prevention Molecular Biology |
institution |
De La Salle University |
building |
De La Salle University Library |
continent |
Asia |
country |
Philippines Philippines |
content_provider |
De La Salle University Library |
collection |
DLSU Institutional Repository |
topic |
Glycerin Molecular chaperones Aging—Prevention Molecular Biology |
spellingShingle |
Glycerin Molecular chaperones Aging—Prevention Molecular Biology Deocaris, Custer C. Shrestha, Bhupal G. Kraft, David C. Yamasaki, Kazuhiko Rattan, Suresh I. S. Wadhwa, Renu Geoprotection by glycerol: Insights to its mechanisms and critical potentials |
description |
Chaperones, particularly the heat-shock proteins, are considered as key players in the maintenance of protein homeostasis and are associated with longevity and cellular immortalization. In this study, we investigated the geroprotective activity of the chemical chaperone glycerol. Glycerol showed significant chaperoning activity in refolding heat-denatured luciferase in vivo and in protecting cells from heat stress-induced cytotoxicity. This was accompanied by decrease in p53, an upregulation of a stress chaperone mortalin/mtHsp70, and an increase in proteasome activity in the presence of oxidative stress. |
format |
text |
author |
Deocaris, Custer C. Shrestha, Bhupal G. Kraft, David C. Yamasaki, Kazuhiko Rattan, Suresh I. S. Wadhwa, Renu |
author_facet |
Deocaris, Custer C. Shrestha, Bhupal G. Kraft, David C. Yamasaki, Kazuhiko Rattan, Suresh I. S. Wadhwa, Renu |
author_sort |
Deocaris, Custer C. |
title |
Geoprotection by glycerol: Insights to its mechanisms and critical potentials |
title_short |
Geoprotection by glycerol: Insights to its mechanisms and critical potentials |
title_full |
Geoprotection by glycerol: Insights to its mechanisms and critical potentials |
title_fullStr |
Geoprotection by glycerol: Insights to its mechanisms and critical potentials |
title_full_unstemmed |
Geoprotection by glycerol: Insights to its mechanisms and critical potentials |
title_sort |
geoprotection by glycerol: insights to its mechanisms and critical potentials |
publisher |
Animo Repository |
publishDate |
2006 |
url |
https://animorepository.dlsu.edu.ph/faculty_research/5466 |
_version_ |
1767196309939290112 |