Trendy RNA tools for aging research

Aging is an inevitable biological phenomenon. Attempts to understand its mechanisms and, consequently, to therapeutically decelerate or even reverse the process are limited by its daunting complexity. Rapid and robust functional genomic tools suited to a wide array of experimental model systems are...

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Main Authors: Deocaris, Custer C., Kaul, Sunil C., Taira, Kazunari, Wadhwa, Renu
Format: text
Published: Animo Repository 2004
Subjects:
RNA
Online Access:https://animorepository.dlsu.edu.ph/faculty_research/5454
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Institution: De La Salle University
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spelling oai:animorepository.dlsu.edu.ph:faculty_research-62642022-04-20T06:58:19Z Trendy RNA tools for aging research Deocaris, Custer C. Kaul, Sunil C. Taira, Kazunari Wadhwa, Renu Aging is an inevitable biological phenomenon. Attempts to understand its mechanisms and, consequently, to therapeutically decelerate or even reverse the process are limited by its daunting complexity. Rapid and robust functional genomic tools suited to a wide array of experimental model systems are needed to dissect the interplay of individual genes during aging. In this article, we review principles that transcend the view of RNA, from a molecule merely mediating the flow of genetic information, into a unique molecular tool. In the form of catalytic molecular scissors (ribozymes), antibody-like antagonists (aptamers) and gene silencers (interfering RNAs, RNAi) can be effectively used to dissect biofunctions conserved throughout the evolution. In this review, application of recent RNA tools in aging research is discussed. 2004-01-01T08:00:00Z text https://animorepository.dlsu.edu.ph/faculty_research/5454 Faculty Research Work Animo Repository RNA Aging—Genetic aspects Cell and Developmental Biology
institution De La Salle University
building De La Salle University Library
continent Asia
country Philippines
Philippines
content_provider De La Salle University Library
collection DLSU Institutional Repository
topic RNA
Aging—Genetic aspects
Cell and Developmental Biology
spellingShingle RNA
Aging—Genetic aspects
Cell and Developmental Biology
Deocaris, Custer C.
Kaul, Sunil C.
Taira, Kazunari
Wadhwa, Renu
Trendy RNA tools for aging research
description Aging is an inevitable biological phenomenon. Attempts to understand its mechanisms and, consequently, to therapeutically decelerate or even reverse the process are limited by its daunting complexity. Rapid and robust functional genomic tools suited to a wide array of experimental model systems are needed to dissect the interplay of individual genes during aging. In this article, we review principles that transcend the view of RNA, from a molecule merely mediating the flow of genetic information, into a unique molecular tool. In the form of catalytic molecular scissors (ribozymes), antibody-like antagonists (aptamers) and gene silencers (interfering RNAs, RNAi) can be effectively used to dissect biofunctions conserved throughout the evolution. In this review, application of recent RNA tools in aging research is discussed.
format text
author Deocaris, Custer C.
Kaul, Sunil C.
Taira, Kazunari
Wadhwa, Renu
author_facet Deocaris, Custer C.
Kaul, Sunil C.
Taira, Kazunari
Wadhwa, Renu
author_sort Deocaris, Custer C.
title Trendy RNA tools for aging research
title_short Trendy RNA tools for aging research
title_full Trendy RNA tools for aging research
title_fullStr Trendy RNA tools for aging research
title_full_unstemmed Trendy RNA tools for aging research
title_sort trendy rna tools for aging research
publisher Animo Repository
publishDate 2004
url https://animorepository.dlsu.edu.ph/faculty_research/5454
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