Computational ligand-based molecular analysis of kaurenoic acid and kaurane diterpene derivatives as NF-kB pathway inhibitors

• Main Authors: Inoue, Rinnalyn N., Nonato, Maybel M., Janairo, Jose Isagani B., Yu, Derrick Ethelbhert C.
• Format: text
• Published: Animo Repository 2012
• Subjects: NF-kappa B (DNA-binding protein); Enzyme inhibitors; Metabolites; Diterpenes; Atomic, Molecular and Optical Physics
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/6599
• Institution: De La Salle University

Kaurenoic acid derivatives and kaurane diterpenes are known to be inhibitors of the NF-kB pathway wherein both compounds share the same tetracyclic structure. Despite sharing close structural homology, Kaurenoic acid derivatives exert their activity through IKK inhibition whereas Kaurane diterpenes...