Synthesis of two novel isonicotinoylhydrazones

• Main Authors: Alea, Glenn V., Aguirre, Paolo Miguel G., Lustestica, Kaye Eunice L., Ajero, Michael Dominic M., Lagua, Faith Marie G.
• Format: text
• Published: Animo Repository 2010
• Subjects: Isoniazid—Synthesis; Mycobacterium tuberculosis; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/7782
• Institution: De La Salle University

Isonicotinoylhydrazone derivatives of methy 5-acetylsalicylate (2) and methyl 5-octanoylasalicylate (4) were synthesized and characterized. The synthesis involves the Friedel-Crafts acylation of methyl salicylate with acetyl chloride and octanoyl chloride using ZnCl2 as catalyst to generate the meth...