Synthesis of 2-hydroxy-5-(1-(2-(pyrazine-2-carbonyl) hydrazono) hexyl) benzoic acid, a pyrazinamide analog of salicylic acid
The occurrence of resistant strains of Mycobacterium tuberculosis has driven current research on combining current anti-tuberculosis drugs and other bioactive molecules to enhance their efficacy against susceptible and resistant strains of the bacteria. In this study, a salicylic acid derivative of...
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oai:animorepository.dlsu.edu.ph:faculty_research-87192022-12-17T00:44:33Z Synthesis of 2-hydroxy-5-(1-(2-(pyrazine-2-carbonyl) hydrazono) hexyl) benzoic acid, a pyrazinamide analog of salicylic acid Alea, Glenn V. Abarquez, Anna Carmina S. Austria, Michelle Pia B. Lim, Alan Christian S. Lagua, Faith Marie G. Ajero, Michael Dominic M. The occurrence of resistant strains of Mycobacterium tuberculosis has driven current research on combining current anti-tuberculosis drugs and other bioactive molecules to enhance their efficacy against susceptible and resistant strains of the bacteria. In this study, a salicylic acid derivative of pyrazinamide, 2-hydroxy-5-(1-(2-(pyrazine-2-carbonyl) hydrazono) hexyl) benzoic acid was synthesized and characterized. The compound was prepared by coupling a pyrazinamide moiety, one of the first line drugs used to treat tuberculosis and a salicylic acid derivative with a 6-carbon alkyl chain. The salicylic acid derivative was generated via Friedel-Crafts acylation of methyl salicylate followed by base hydrolysis of the acylated product. This was coupled with the pyrazinamide moiety via imine formation. The product, 2-hydroxy-5-(1-(2-(pyrazine-2-carbonyl) hydrazono) hexyl) benzoic acid was obtained as an off-white powder in 62% yield. 2013-01-01T08:00:00Z text https://animorepository.dlsu.edu.ph/faculty_research/7974 Faculty Research Work Animo Repository Pyrazinamide—Synthesis Mycobacterium tuberculosis Salicylic acid Imines Acylation Chemistry |
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Pyrazinamide—Synthesis Mycobacterium tuberculosis Salicylic acid Imines Acylation Chemistry |
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Pyrazinamide—Synthesis Mycobacterium tuberculosis Salicylic acid Imines Acylation Chemistry Alea, Glenn V. Abarquez, Anna Carmina S. Austria, Michelle Pia B. Lim, Alan Christian S. Lagua, Faith Marie G. Ajero, Michael Dominic M. Synthesis of 2-hydroxy-5-(1-(2-(pyrazine-2-carbonyl) hydrazono) hexyl) benzoic acid, a pyrazinamide analog of salicylic acid |
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The occurrence of resistant strains of Mycobacterium tuberculosis has driven current research on combining current anti-tuberculosis drugs and other bioactive molecules to enhance their efficacy against susceptible and resistant strains of the bacteria. In this study, a salicylic acid derivative of pyrazinamide, 2-hydroxy-5-(1-(2-(pyrazine-2-carbonyl) hydrazono) hexyl) benzoic acid was synthesized and characterized. The compound was prepared by coupling a pyrazinamide moiety, one of the first line drugs used to treat tuberculosis and a salicylic acid derivative with a 6-carbon alkyl chain. The salicylic acid derivative was generated via Friedel-Crafts acylation of methyl salicylate followed by base hydrolysis of the acylated product. This was coupled with the pyrazinamide moiety via imine formation. The product, 2-hydroxy-5-(1-(2-(pyrazine-2-carbonyl) hydrazono) hexyl) benzoic acid was obtained as an off-white powder in 62% yield. |
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Alea, Glenn V. Abarquez, Anna Carmina S. Austria, Michelle Pia B. Lim, Alan Christian S. Lagua, Faith Marie G. Ajero, Michael Dominic M. |
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Alea, Glenn V. Abarquez, Anna Carmina S. Austria, Michelle Pia B. Lim, Alan Christian S. Lagua, Faith Marie G. Ajero, Michael Dominic M. |
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Alea, Glenn V. |
title |
Synthesis of 2-hydroxy-5-(1-(2-(pyrazine-2-carbonyl) hydrazono) hexyl) benzoic acid, a pyrazinamide analog of salicylic acid |
title_short |
Synthesis of 2-hydroxy-5-(1-(2-(pyrazine-2-carbonyl) hydrazono) hexyl) benzoic acid, a pyrazinamide analog of salicylic acid |
title_full |
Synthesis of 2-hydroxy-5-(1-(2-(pyrazine-2-carbonyl) hydrazono) hexyl) benzoic acid, a pyrazinamide analog of salicylic acid |
title_fullStr |
Synthesis of 2-hydroxy-5-(1-(2-(pyrazine-2-carbonyl) hydrazono) hexyl) benzoic acid, a pyrazinamide analog of salicylic acid |
title_full_unstemmed |
Synthesis of 2-hydroxy-5-(1-(2-(pyrazine-2-carbonyl) hydrazono) hexyl) benzoic acid, a pyrazinamide analog of salicylic acid |
title_sort |
synthesis of 2-hydroxy-5-(1-(2-(pyrazine-2-carbonyl) hydrazono) hexyl) benzoic acid, a pyrazinamide analog of salicylic acid |
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Animo Repository |
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2013 |
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https://animorepository.dlsu.edu.ph/faculty_research/7974 |
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