Non-Coding RNAs Involved in the Molecular Pathology of Alzheimer’s Disease: A Systematic Review

Alzheimer’s disease (AD) is the leading cause of dementia globally, having a pathophysiology that is complex and multifactorial. Recent findings highlight the significant role of non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and...

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Main Authors: Canoy, Reynand Jay, Sy, Jenica Clarisse, Deguit, Christian Deo, Castro, Caitlin Bridgette, Dimaapi, Lyoneil James, Panlaqui, Beatrice Gabrielle, Perian, Wenzel, Yu, Justine, Velasco, John Mark, Sevilleja, Jesus Emmanuel, Gibson, Anna
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Published: Archīum Ateneo 2024
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Online Access:https://archium.ateneo.edu/asmph-pubs/252
https://archium.ateneo.edu/context/asmph-pubs/article/1256/viewcontent/fnins_18_1421675.pdf
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spelling ph-ateneo-arc.asmph-pubs-12562024-09-19T06:27:00Z Non-Coding RNAs Involved in the Molecular Pathology of Alzheimer’s Disease: A Systematic Review Canoy, Reynand Jay Sy, Jenica Clarisse Deguit, Christian Deo Castro, Caitlin Bridgette Dimaapi, Lyoneil James Panlaqui, Beatrice Gabrielle Perian, Wenzel Yu, Justine Velasco, John Mark Sevilleja, Jesus Emmanuel Gibson, Anna Alzheimer’s disease (AD) is the leading cause of dementia globally, having a pathophysiology that is complex and multifactorial. Recent findings highlight the significant role of non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and piwi-interacting RNAs (piRNAs) in the molecular mechanisms underlying AD. These ncRNAs are involved in critical biological processes such as cell proliferation, apoptosis, oxidative stress, amyloid-beta aggregation, tau phosphorylation, neuroinflammation, and autophagy, which are pivotal in AD development and progression. This systematic review aims to consolidate current scientific knowledge on the role of ncRNAs in AD, making it the first to encompass the four types of ncRNAs associated with the disease. Our comprehensive search and analysis reveal that ncRNAs not only play crucial roles in the pathogenesis of AD but also hold potential as biomarkers for its early detection and as novel therapeutic targets. Specifically, the findings underscore the significance of miRNAs in regulating genes involved in key AD pathways such as activin receptor signaling pathway, actomyosin contractile ring organization, and advanced glycation endproducts-receptor advanced glycation endproducts (AGE-RAGE) signaling pathway. This review also highlights the potential of ncRNAs in unveiling novel diagnostic and therapeutic strategies, emphasizing the need for further research to validate their clinical utility. Our systematic exploration provides a foundation for future bioinformatic analyses and the development of ncRNA-based precision medicine approaches for AD, offering new insights into the disease’s molecular pathology and paving the way for innovative treatment strategies. 2024-01-01T08:00:00Z text application/pdf https://archium.ateneo.edu/asmph-pubs/252 https://archium.ateneo.edu/context/asmph-pubs/article/1256/viewcontent/fnins_18_1421675.pdf Ateneo School of Medicine and Public Health Publications Archīum Ateneo Alzheimer’s disease biomarkers circRNA lncRNA miRNA molecular pathology ncRNA piRNA Diseases Medicine and Health Sciences Nervous System Diseases Neurology Pathology
institution Ateneo De Manila University
building Ateneo De Manila University Library
continent Asia
country Philippines
Philippines
content_provider Ateneo De Manila University Library
collection archium.Ateneo Institutional Repository
topic Alzheimer’s disease
biomarkers
circRNA
lncRNA
miRNA
molecular pathology
ncRNA
piRNA
Diseases
Medicine and Health Sciences
Nervous System Diseases
Neurology
Pathology
spellingShingle Alzheimer’s disease
biomarkers
circRNA
lncRNA
miRNA
molecular pathology
ncRNA
piRNA
Diseases
Medicine and Health Sciences
Nervous System Diseases
Neurology
Pathology
Canoy, Reynand Jay
Sy, Jenica Clarisse
Deguit, Christian Deo
Castro, Caitlin Bridgette
Dimaapi, Lyoneil James
Panlaqui, Beatrice Gabrielle
Perian, Wenzel
Yu, Justine
Velasco, John Mark
Sevilleja, Jesus Emmanuel
Gibson, Anna
Non-Coding RNAs Involved in the Molecular Pathology of Alzheimer’s Disease: A Systematic Review
description Alzheimer’s disease (AD) is the leading cause of dementia globally, having a pathophysiology that is complex and multifactorial. Recent findings highlight the significant role of non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and piwi-interacting RNAs (piRNAs) in the molecular mechanisms underlying AD. These ncRNAs are involved in critical biological processes such as cell proliferation, apoptosis, oxidative stress, amyloid-beta aggregation, tau phosphorylation, neuroinflammation, and autophagy, which are pivotal in AD development and progression. This systematic review aims to consolidate current scientific knowledge on the role of ncRNAs in AD, making it the first to encompass the four types of ncRNAs associated with the disease. Our comprehensive search and analysis reveal that ncRNAs not only play crucial roles in the pathogenesis of AD but also hold potential as biomarkers for its early detection and as novel therapeutic targets. Specifically, the findings underscore the significance of miRNAs in regulating genes involved in key AD pathways such as activin receptor signaling pathway, actomyosin contractile ring organization, and advanced glycation endproducts-receptor advanced glycation endproducts (AGE-RAGE) signaling pathway. This review also highlights the potential of ncRNAs in unveiling novel diagnostic and therapeutic strategies, emphasizing the need for further research to validate their clinical utility. Our systematic exploration provides a foundation for future bioinformatic analyses and the development of ncRNA-based precision medicine approaches for AD, offering new insights into the disease’s molecular pathology and paving the way for innovative treatment strategies.
format text
author Canoy, Reynand Jay
Sy, Jenica Clarisse
Deguit, Christian Deo
Castro, Caitlin Bridgette
Dimaapi, Lyoneil James
Panlaqui, Beatrice Gabrielle
Perian, Wenzel
Yu, Justine
Velasco, John Mark
Sevilleja, Jesus Emmanuel
Gibson, Anna
author_facet Canoy, Reynand Jay
Sy, Jenica Clarisse
Deguit, Christian Deo
Castro, Caitlin Bridgette
Dimaapi, Lyoneil James
Panlaqui, Beatrice Gabrielle
Perian, Wenzel
Yu, Justine
Velasco, John Mark
Sevilleja, Jesus Emmanuel
Gibson, Anna
author_sort Canoy, Reynand Jay
title Non-Coding RNAs Involved in the Molecular Pathology of Alzheimer’s Disease: A Systematic Review
title_short Non-Coding RNAs Involved in the Molecular Pathology of Alzheimer’s Disease: A Systematic Review
title_full Non-Coding RNAs Involved in the Molecular Pathology of Alzheimer’s Disease: A Systematic Review
title_fullStr Non-Coding RNAs Involved in the Molecular Pathology of Alzheimer’s Disease: A Systematic Review
title_full_unstemmed Non-Coding RNAs Involved in the Molecular Pathology of Alzheimer’s Disease: A Systematic Review
title_sort non-coding rnas involved in the molecular pathology of alzheimer’s disease: a systematic review
publisher Archīum Ateneo
publishDate 2024
url https://archium.ateneo.edu/asmph-pubs/252
https://archium.ateneo.edu/context/asmph-pubs/article/1256/viewcontent/fnins_18_1421675.pdf
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