Tranexamic Acid as Treatment for Acute Gastrointestinal Bleeding: A Comprehensive Systematic Review and Meta-analysis

• Main Authors: Calderon Martinez, Ernesto, Briceño Silva, Gabriela D., Sanchez Cruz, Camila, Woldehana, Nathnael Abera, Shah, Yash, Dahiya, Dushyant Singh, Gangwani, Manesh Kumar, Chandan, Saurabh, Caliwag, Fides Myles C., Maldonado, Rodrigo Sebastian, Bolivar-Barrios, Rubeliz, Motino, Ada, Advani, Rashmi
• Format: text
• Published: Archīum Ateneo 2025
• Subjects: Antifibrinolytics; Gastrointestinal bleeding; GI gastrointestinal; RCTs randomized controlled trials; RR relative risk; Thrombotic events; Tranexamic acid; Gastroenterology; Medicine and Health Sciences
• Online Access: https://archium.ateneo.edu/asmph-pubs/299; https://doi.org/10.1007/s12664-025-01749-9

Introduction Gastrointestinal (GI) bleeding is a common and potentially life-threatening medical emergency. Despite advancements in therapy, mortality rates associated with GI bleeding remain high (2.4% to 11%). Tranexamic acid (TXA) has been proposed as a treatment. However, the HALT-IT trial quest...