Untargeted Bioassay Strategy for Medicinal Plants: In Vitro Antidiabetic Activity and 13C NMR Profiling of Extracts from Vitex negundo L

• Main Authors: Dayrit, Fabian M, Zabala, Myrnille Joy B, Lagurin, Lolita G
• Format: text
• Published: Archīum Ateneo 2018
• Subjects: Vitex negundo L; Untargeted bioassay; Glucose diffusion retardation index; Alpha-amylase inhibition; Multivariate correlation; 13C NMR profiling; Match factor; Biochemistry; Medicinal-Pharmaceutical Chemistry
• Online Access: https://archium.ateneo.edu/chemistry-faculty-pubs/27; https://archium.ateneo.edu/cgi/viewcontent.cgi?article=1026&context=chemistry-faculty-pubs
• Institution: Ateneo De Manila University

Bioassay-guided fractionation is the principal method for the identification of active constituents in medicinal plants. By design, this method aims to identify the most active compound in a complex mixture with the objective of discovering novel drug candidates. Described here is a complementary me...