Chitosan and Quat-188 Modified Chitosan Poly(acrylic acid) Semi-Interpenetrating Network For Controlled Release of Drugs

Semi-interpenetrating polymer networks (semi-IPNs) composed of polyacrylic acid (PAA), and chitosan or N-(3-chloro-2-hydroxypropyl)trimethylammonium chloride (Quat-188) modified chitosan were synthesized. To fabricate the semi-IPN, acrylic acid (AA) was polymerized and crosslinked in the presence of...

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Main Authors: Benitez, Christian Jil R, Gonzales, Christian, Leal, Mari Kaira O, Andalis, Ivy Marie C, Chua, Modesto Tan, Nakaoki, Takahiko, Chakraborty, Soma
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Published: Archīum Ateneo 2015
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Online Access:https://archium.ateneo.edu/chemistry-faculty-pubs/39
https://kimika.pfcs.org.ph/index.php/kimika/article/view/182
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spelling ph-ateneo-arc.chemistry-faculty-pubs-10382020-06-05T06:58:46Z Chitosan and Quat-188 Modified Chitosan Poly(acrylic acid) Semi-Interpenetrating Network For Controlled Release of Drugs Benitez, Christian Jil R Gonzales, Christian Leal, Mari Kaira O Andalis, Ivy Marie C Chua, Modesto Tan Nakaoki, Takahiko Chakraborty, Soma Semi-interpenetrating polymer networks (semi-IPNs) composed of polyacrylic acid (PAA), and chitosan or N-(3-chloro-2-hydroxypropyl)trimethylammonium chloride (Quat-188) modified chitosan were synthesized. To fabricate the semi-IPN, acrylic acid (AA) was polymerized and crosslinked in the presence of unmodified and Quat-188 modified chitosan. The wet strength of the semi-IPNs improved with the increase in molecular weight of chitosan, chitosan to PAA ratio and by Quat-188 modification. Both modified and unmodified semi-IPNs swelled in buffer solutions. Swelling was pH dependent. The mode of encapsulation and release of two different types of drugs from these semi IPNs was studied. Effects of various parameters on encapsulation and release of AgNO3 and mafenide acetate from these semi-IPNs were investigated. The semi-IPN hydrogel encapsulated 10 mmol/L AgNO3 (100% of added drug) in 5min and released 4% of it in 2h. In case of mafenide acetate, pH dependent encapsulation and controlled release was observed. It was observed that drug-semi IPN interaction strongly influences the encapsulation and release behavior. Freezable water associated with the hydrogels also played an important role for the encapsulation and release of drug. 2015-01-01T08:00:00Z text https://archium.ateneo.edu/chemistry-faculty-pubs/39 https://kimika.pfcs.org.ph/index.php/kimika/article/view/182 Chemistry Faculty Publications Archīum Ateneo chitosan controlled drug delivery hydrogel Quat-188 poly(acrylic acid) Chemistry
institution Ateneo De Manila University
building Ateneo De Manila University Library
continent Asia
country Philippines
Philippines
content_provider Ateneo De Manila University Library
collection archium.Ateneo Institutional Repository
topic chitosan
controlled drug delivery
hydrogel
Quat-188
poly(acrylic acid)
Chemistry
spellingShingle chitosan
controlled drug delivery
hydrogel
Quat-188
poly(acrylic acid)
Chemistry
Benitez, Christian Jil R
Gonzales, Christian
Leal, Mari Kaira O
Andalis, Ivy Marie C
Chua, Modesto Tan
Nakaoki, Takahiko
Chakraborty, Soma
Chitosan and Quat-188 Modified Chitosan Poly(acrylic acid) Semi-Interpenetrating Network For Controlled Release of Drugs
description Semi-interpenetrating polymer networks (semi-IPNs) composed of polyacrylic acid (PAA), and chitosan or N-(3-chloro-2-hydroxypropyl)trimethylammonium chloride (Quat-188) modified chitosan were synthesized. To fabricate the semi-IPN, acrylic acid (AA) was polymerized and crosslinked in the presence of unmodified and Quat-188 modified chitosan. The wet strength of the semi-IPNs improved with the increase in molecular weight of chitosan, chitosan to PAA ratio and by Quat-188 modification. Both modified and unmodified semi-IPNs swelled in buffer solutions. Swelling was pH dependent. The mode of encapsulation and release of two different types of drugs from these semi IPNs was studied. Effects of various parameters on encapsulation and release of AgNO3 and mafenide acetate from these semi-IPNs were investigated. The semi-IPN hydrogel encapsulated 10 mmol/L AgNO3 (100% of added drug) in 5min and released 4% of it in 2h. In case of mafenide acetate, pH dependent encapsulation and controlled release was observed. It was observed that drug-semi IPN interaction strongly influences the encapsulation and release behavior. Freezable water associated with the hydrogels also played an important role for the encapsulation and release of drug.
format text
author Benitez, Christian Jil R
Gonzales, Christian
Leal, Mari Kaira O
Andalis, Ivy Marie C
Chua, Modesto Tan
Nakaoki, Takahiko
Chakraborty, Soma
author_facet Benitez, Christian Jil R
Gonzales, Christian
Leal, Mari Kaira O
Andalis, Ivy Marie C
Chua, Modesto Tan
Nakaoki, Takahiko
Chakraborty, Soma
author_sort Benitez, Christian Jil R
title Chitosan and Quat-188 Modified Chitosan Poly(acrylic acid) Semi-Interpenetrating Network For Controlled Release of Drugs
title_short Chitosan and Quat-188 Modified Chitosan Poly(acrylic acid) Semi-Interpenetrating Network For Controlled Release of Drugs
title_full Chitosan and Quat-188 Modified Chitosan Poly(acrylic acid) Semi-Interpenetrating Network For Controlled Release of Drugs
title_fullStr Chitosan and Quat-188 Modified Chitosan Poly(acrylic acid) Semi-Interpenetrating Network For Controlled Release of Drugs
title_full_unstemmed Chitosan and Quat-188 Modified Chitosan Poly(acrylic acid) Semi-Interpenetrating Network For Controlled Release of Drugs
title_sort chitosan and quat-188 modified chitosan poly(acrylic acid) semi-interpenetrating network for controlled release of drugs
publisher Archīum Ateneo
publishDate 2015
url https://archium.ateneo.edu/chemistry-faculty-pubs/39
https://kimika.pfcs.org.ph/index.php/kimika/article/view/182
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