Screening of plant constituents for effect on glucose transport activity in Ehrlich ascites tumour cells

Screening of plant constituents for effect on glucose transport activity in Ehrlich ascites tumour cells

The effect of plant extracts on D-glucose uptake by Ehrlich ascites tumour cells was examined. Among the 23 exracts of medicinal plants, five samples inhibited, and six samples activated, the uptake significantly. From one of the active plants, Lagerstroemia speciosa, two triterpenoids, colosolic ac...

Full description

Saved in:
Bibliographic Details
Main Authors: Murakami, Chikage, Myoga, Keiko, Kasai, Ryoji, Ohtani, Kazuhiro, Kurokawa, Tomonori, Ishibashi, Sadahiko, Dayrit, Fabian M, Padolina, William G, Yamasaki, Kazuo
Format: text
Published: Archīum Ateneo 1993
Subjects:
glucose transport
antidiabetic
Lagerstroemia speciosa
Lythraceae
triterpene
colosolic acid
Biochemistry
Chemistry
Online Access:https://archium.ateneo.edu/chemistry-faculty-pubs/95
https://www.jstage.jst.go.jp/article/cpb1958/41/12/41_12_2129/_article/-char/ja/
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Ateneo De Manila University
Description
Summary:The effect of plant extracts on D-glucose uptake by Ehrlich ascites tumour cells was examined. Among the 23 exracts of medicinal plants, five samples inhibited, and six samples activated, the uptake significantly. From one of the active plants, Lagerstroemia speciosa, two triterpenoids, colosolic acid and maslinic acid were isolated. Colosolic acid was shown to be a glucose transport activator. Scince this compound was known to have hypoglycemic activity, our simple in vitro bioassay method can at least be used as a first screening for anti-diabetic activity.

Similar Items