Zebrafish Bioassay-Guided Microfractionation Identifies Anticonvulsant Steroid Glycosides from the Philippine Medicinal Plant Solanum torvum

• Main Authors: Challal, Soura, Buenafe, Olivia Erin M, Quiroz, Emerson F, Maljevic, Snezana, Marcourt, Laurence, Bock, Merle, Kloeti, Werner, Dayrit, Fabian M, Harvey, Alan L, Lerche, Holger, Esguerra, Camila V, de Witte, Peter A M, Wolfender, Jean-Luc, Crawford, Alexander D
• Format: text
• Published: Archīum Ateneo 2014
• Subjects: Zebrafish HPLC microfractionation Solanum torvum Solanaceae saponins antiepileptic activity; Chemistry; Medicinal and Pharmaceutical Chemistry
• Online Access: https://archium.ateneo.edu/chemistry-faculty-pubs/111; https://pubs.acs.org/doi/abs/10.1021/cn5001342
• Institution: Ateneo De Manila University

Medicinal plants used for the treatment of epilepsy are potentially a valuable source of novel antiepileptic small molecules. To identify anticonvulsant secondary metabolites, we performed an in vivo, zebrafish-based screen of medicinal plants used in Southeast Asia for the treatment of seizures. So...