Synthesis of copper-silver doped hydroxyapatite via ultrasonic coupled sol-gel techniques: structural and antibacterial studies

Fabrication of hydroxyapatite (HA) via doping with metal ions to enhance its antibacterial properties has attracted much interest. The present study aims to synthesize copper-silver doped hydroxyapatite particles (Cu-Ag doped HA) with an improved antibacterial activity through a sol-gel technique co...

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Main Authors: Kamonwannasit, S, Futalan, CM, Khemthong, P, Butburee, T, Karaphun, A, Phatai, P
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Published: Archīum Ateneo 2020
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Online Access:https://archium.ateneo.edu/es-faculty-pubs/67
https://link.springer.com/article/10.1007/s10971-020-05407-8
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spelling ph-ateneo-arc.es-faculty-pubs-10662021-07-09T10:34:32Z Synthesis of copper-silver doped hydroxyapatite via ultrasonic coupled sol-gel techniques: structural and antibacterial studies Kamonwannasit, S Futalan, CM Khemthong, P Butburee, T Karaphun, A Phatai, P Fabrication of hydroxyapatite (HA) via doping with metal ions to enhance its antibacterial properties has attracted much interest. The present study aims to synthesize copper-silver doped hydroxyapatite particles (Cu-Ag doped HA) with an improved antibacterial activity through a sol-gel technique coupled with ultrasonic irradiation. The doping materials consist of Cu2+ and Ag+ ions with precursor molar ratios of 0.0, 0.25, 0.50, 0.75 and 1.0. The physicochemical properties of Ca9.0Cu1.0-xAgx(PO4)6(OH)2 samples were investigated using X-ray diffraction, Fourier-transform infrared spectroscopy (FT-IR), and transmission electron microscopy coupled with energy dispersive X-ray analysis (TEM-EDS). Characterization studies revealed that Cu2+ and Ag+ ions were incorporated into a hexagonal framework of HA. The main functional groups were identified as hydroxyl (OH−) and phosphate (PO43−) moieties. Their morphologies were rod-shaped with various diameters and particle size distributions, depending on the molar ratio of Cu2+ to Ag+. Antibacterial activity was evaluated using an agar well diffusion method against Staphylococcus epidermis, S. aureus, Bacillus subtilis, B. cereus, and Pseudomonas aeruginosa. It was found that Cu-Ag doped HA is an effective antibacterial agent. Ca9.0Cu0.5Ag0.5(PO4)6(OH)2 showed the best antibacterial performance against all bacterial strains with inhibition zones ranging from 13 to 17 mm, indicating its suitability as an antibacterial material in biomedical applications. 2020-01-01T08:00:00Z text https://archium.ateneo.edu/es-faculty-pubs/67 https://link.springer.com/article/10.1007/s10971-020-05407-8 Environmental Science Faculty Publications Archīum Ateneo Antibacterial activity Copper Hydroxyapatite Silver Sol-gel technique Environmental Sciences Other Environmental Sciences
institution Ateneo De Manila University
building Ateneo De Manila University Library
continent Asia
country Philippines
Philippines
content_provider Ateneo De Manila University Library
collection archium.Ateneo Institutional Repository
topic Antibacterial activity
Copper
Hydroxyapatite
Silver
Sol-gel technique
Environmental Sciences
Other Environmental Sciences
spellingShingle Antibacterial activity
Copper
Hydroxyapatite
Silver
Sol-gel technique
Environmental Sciences
Other Environmental Sciences
Kamonwannasit, S
Futalan, CM
Khemthong, P
Butburee, T
Karaphun, A
Phatai, P
Synthesis of copper-silver doped hydroxyapatite via ultrasonic coupled sol-gel techniques: structural and antibacterial studies
description Fabrication of hydroxyapatite (HA) via doping with metal ions to enhance its antibacterial properties has attracted much interest. The present study aims to synthesize copper-silver doped hydroxyapatite particles (Cu-Ag doped HA) with an improved antibacterial activity through a sol-gel technique coupled with ultrasonic irradiation. The doping materials consist of Cu2+ and Ag+ ions with precursor molar ratios of 0.0, 0.25, 0.50, 0.75 and 1.0. The physicochemical properties of Ca9.0Cu1.0-xAgx(PO4)6(OH)2 samples were investigated using X-ray diffraction, Fourier-transform infrared spectroscopy (FT-IR), and transmission electron microscopy coupled with energy dispersive X-ray analysis (TEM-EDS). Characterization studies revealed that Cu2+ and Ag+ ions were incorporated into a hexagonal framework of HA. The main functional groups were identified as hydroxyl (OH−) and phosphate (PO43−) moieties. Their morphologies were rod-shaped with various diameters and particle size distributions, depending on the molar ratio of Cu2+ to Ag+. Antibacterial activity was evaluated using an agar well diffusion method against Staphylococcus epidermis, S. aureus, Bacillus subtilis, B. cereus, and Pseudomonas aeruginosa. It was found that Cu-Ag doped HA is an effective antibacterial agent. Ca9.0Cu0.5Ag0.5(PO4)6(OH)2 showed the best antibacterial performance against all bacterial strains with inhibition zones ranging from 13 to 17 mm, indicating its suitability as an antibacterial material in biomedical applications.
format text
author Kamonwannasit, S
Futalan, CM
Khemthong, P
Butburee, T
Karaphun, A
Phatai, P
author_facet Kamonwannasit, S
Futalan, CM
Khemthong, P
Butburee, T
Karaphun, A
Phatai, P
author_sort Kamonwannasit, S
title Synthesis of copper-silver doped hydroxyapatite via ultrasonic coupled sol-gel techniques: structural and antibacterial studies
title_short Synthesis of copper-silver doped hydroxyapatite via ultrasonic coupled sol-gel techniques: structural and antibacterial studies
title_full Synthesis of copper-silver doped hydroxyapatite via ultrasonic coupled sol-gel techniques: structural and antibacterial studies
title_fullStr Synthesis of copper-silver doped hydroxyapatite via ultrasonic coupled sol-gel techniques: structural and antibacterial studies
title_full_unstemmed Synthesis of copper-silver doped hydroxyapatite via ultrasonic coupled sol-gel techniques: structural and antibacterial studies
title_sort synthesis of copper-silver doped hydroxyapatite via ultrasonic coupled sol-gel techniques: structural and antibacterial studies
publisher Archīum Ateneo
publishDate 2020
url https://archium.ateneo.edu/es-faculty-pubs/67
https://link.springer.com/article/10.1007/s10971-020-05407-8
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