Previous and active tuberculosis increases risk of death and prolongs recovery in patients with COVID-19

Background: There is a growing literature on the association of SARS-CoV-2 and other chronic conditions, such as noncommunicable diseases. However, little is known about the impact of coinfection with tuberculosis. We aimed to compare the risk of death and recovery, as well as time-to-death and time...

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Main Authors: Sy, Karla Therese L, Haw, Nel Jason L, Uy, Jhanna
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Published: Archīum Ateneo 2020
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Online Access:https://archium.ateneo.edu/hs-faculty-pubs/3
https://archium.ateneo.edu/cgi/viewcontent.cgi?article=1002&context=hs-faculty-pubs
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spelling ph-ateneo-arc.hs-faculty-pubs-10022021-01-13T07:02:50Z Previous and active tuberculosis increases risk of death and prolongs recovery in patients with COVID-19 Sy, Karla Therese L Haw, Nel Jason L Uy, Jhanna Background: There is a growing literature on the association of SARS-CoV-2 and other chronic conditions, such as noncommunicable diseases. However, little is known about the impact of coinfection with tuberculosis. We aimed to compare the risk of death and recovery, as well as time-to-death and time-to-recovery, in COVID-19 patients with and without tuberculosis. Methods: We created a 4:1 propensity score matched sample of COVID-19 patients without and with tuberculosis, using COVID-19 surveillance data in the Philippines. We conducted a longitudinal cohort analysis of matched COVID-19 patients as of May 17, 2020, following them until June 15, 2020. The primary analysis estimated the risk ratios of death and recovery in patients with and without tuberculosis. Kaplan–Meier curves described time-to-death and time-to-recovery stratified by tuberculosis status, and differences in survival were assessed using the Wilcoxon test. Results: The risk of death in COVID-19 patients with tuberculosis was 2.17 times higher than in those without (95% CI: 1.40-3.37). The risk of recovery in COVID-19 patients with tuberculosis was 25% lower than in those without (RR ¼ 0.75,05% CI 0.63-0.91). Similarly, time-to-death was significantly shorter (p ¼ .0031) and time-to-recovery significantly longer in patients with tuberculosis (p ¼ .0046). Conclusions: Our findings show that coinfection with tuberculosis increased morbidity and mortality in COVID-19 patients. Our findings highlight the need to prioritize routine and testing services for tuberculosis, although health systems are disrupted by the heavy burden of the SARS-CoV-2 pandemic. 2020-08-08T07:00:00Z text application/pdf https://archium.ateneo.edu/hs-faculty-pubs/3 https://archium.ateneo.edu/cgi/viewcontent.cgi?article=1002&context=hs-faculty-pubs Health Sciences Faculty Publications Archīum Ateneo COVID-19 tuberculosis mortality recovery Medicine and Health Sciences Respiratory Tract Diseases Virus Diseases
institution Ateneo De Manila University
building Ateneo De Manila University Library
continent Asia
country Philippines
Philippines
content_provider Ateneo De Manila University Library
collection archium.Ateneo Institutional Repository
topic COVID-19
tuberculosis
mortality
recovery
Medicine and Health Sciences
Respiratory Tract Diseases
Virus Diseases
spellingShingle COVID-19
tuberculosis
mortality
recovery
Medicine and Health Sciences
Respiratory Tract Diseases
Virus Diseases
Sy, Karla Therese L
Haw, Nel Jason L
Uy, Jhanna
Previous and active tuberculosis increases risk of death and prolongs recovery in patients with COVID-19
description Background: There is a growing literature on the association of SARS-CoV-2 and other chronic conditions, such as noncommunicable diseases. However, little is known about the impact of coinfection with tuberculosis. We aimed to compare the risk of death and recovery, as well as time-to-death and time-to-recovery, in COVID-19 patients with and without tuberculosis. Methods: We created a 4:1 propensity score matched sample of COVID-19 patients without and with tuberculosis, using COVID-19 surveillance data in the Philippines. We conducted a longitudinal cohort analysis of matched COVID-19 patients as of May 17, 2020, following them until June 15, 2020. The primary analysis estimated the risk ratios of death and recovery in patients with and without tuberculosis. Kaplan–Meier curves described time-to-death and time-to-recovery stratified by tuberculosis status, and differences in survival were assessed using the Wilcoxon test. Results: The risk of death in COVID-19 patients with tuberculosis was 2.17 times higher than in those without (95% CI: 1.40-3.37). The risk of recovery in COVID-19 patients with tuberculosis was 25% lower than in those without (RR ¼ 0.75,05% CI 0.63-0.91). Similarly, time-to-death was significantly shorter (p ¼ .0031) and time-to-recovery significantly longer in patients with tuberculosis (p ¼ .0046). Conclusions: Our findings show that coinfection with tuberculosis increased morbidity and mortality in COVID-19 patients. Our findings highlight the need to prioritize routine and testing services for tuberculosis, although health systems are disrupted by the heavy burden of the SARS-CoV-2 pandemic.
format text
author Sy, Karla Therese L
Haw, Nel Jason L
Uy, Jhanna
author_facet Sy, Karla Therese L
Haw, Nel Jason L
Uy, Jhanna
author_sort Sy, Karla Therese L
title Previous and active tuberculosis increases risk of death and prolongs recovery in patients with COVID-19
title_short Previous and active tuberculosis increases risk of death and prolongs recovery in patients with COVID-19
title_full Previous and active tuberculosis increases risk of death and prolongs recovery in patients with COVID-19
title_fullStr Previous and active tuberculosis increases risk of death and prolongs recovery in patients with COVID-19
title_full_unstemmed Previous and active tuberculosis increases risk of death and prolongs recovery in patients with COVID-19
title_sort previous and active tuberculosis increases risk of death and prolongs recovery in patients with covid-19
publisher Archīum Ateneo
publishDate 2020
url https://archium.ateneo.edu/hs-faculty-pubs/3
https://archium.ateneo.edu/cgi/viewcontent.cgi?article=1002&context=hs-faculty-pubs
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