Cyclodextrin Metal-Organic Framework (CD-MOF) synthesis and its application in loading bio-active molecules

Metal-organic frameworks (MOFs) represent an extensive class of porous materials where coordination of metal ions with organic ligands give rise to networks containing potential voids. In the study, colorless cubic crystals of a 'green' cyclodextrin metal-organic framework (CD-MOF) were sy...

Full description

Saved in:
Bibliographic Details
Main Author: PEREZ, YOMKIPPUR
Format: text
Published: Archīum Ateneo 2017
Subjects:
Online Access:https://archium.ateneo.edu/theses-dissertations/125
http://rizalls.lib.admu.edu.ph/#section=resource&resourceid=1193570974&currentIndex=0&view=fullDetailsDetailsTab
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Ateneo De Manila University
id ph-ateneo-arc.theses-dissertations-1124
record_format eprints
spelling ph-ateneo-arc.theses-dissertations-11242021-03-21T12:30:03Z Cyclodextrin Metal-Organic Framework (CD-MOF) synthesis and its application in loading bio-active molecules PEREZ, YOMKIPPUR Metal-organic frameworks (MOFs) represent an extensive class of porous materials where coordination of metal ions with organic ligands give rise to networks containing potential voids. In the study, colorless cubic crystals of a 'green' cyclodextrin metal-organic framework (CD-MOF) were synthesized and its potential to load bio-active molecules such as drugs and enzymes was investigated. Busulfan, an anti-cancer drug widely used to treat chronic myelogenous leukemia was used as test drug while trypsin and lipase were used as model enzymes. The CD-MOFs were prepared by dissolving alkali metal salts and ?-cyclodextrin in water followed by vapor diffusion in varying solvents (methanol, ethanol, acetone and tetrahydrofuran) for several days. Crystals were activated via dichloromethane dispersion and in vacuo drying. Slow vapor diffusion with ethanol was found to give the highest yield and fastest crystallization time among all the solvents used. CD-MOFs synthesized using ethanol were characterized to be cubic crystals with sizes ranging from 1000-100m that are stable up to 250C. Loading of busulfan (%S) onto the CDMOFs and co-crystallization with trypsin (%N) were both successful as confirmed by elemental analysis. Loading studies of busulfan performed using 1H-NMR spectroscopy confirmed about 5 wt% loading in CD-MOFs. 2017-01-01T08:00:00Z text https://archium.ateneo.edu/theses-dissertations/125 http://rizalls.lib.admu.edu.ph/#section=resource&resourceid=1193570974&currentIndex=0&view=fullDetailsDetailsTab Theses and Dissertations (All) Archīum Ateneo Organometallic compounds -- Analysis Organometallic chemistry Cyclodextrins Biomolecules -- Structure Biomolecules -- Analysis.
institution Ateneo De Manila University
building Ateneo De Manila University Library
continent Asia
country Philippines
Philippines
content_provider Ateneo De Manila University Library
collection archium.Ateneo Institutional Repository
topic Organometallic compounds -- Analysis
Organometallic chemistry
Cyclodextrins
Biomolecules -- Structure
Biomolecules -- Analysis.
spellingShingle Organometallic compounds -- Analysis
Organometallic chemistry
Cyclodextrins
Biomolecules -- Structure
Biomolecules -- Analysis.
PEREZ, YOMKIPPUR
Cyclodextrin Metal-Organic Framework (CD-MOF) synthesis and its application in loading bio-active molecules
description Metal-organic frameworks (MOFs) represent an extensive class of porous materials where coordination of metal ions with organic ligands give rise to networks containing potential voids. In the study, colorless cubic crystals of a 'green' cyclodextrin metal-organic framework (CD-MOF) were synthesized and its potential to load bio-active molecules such as drugs and enzymes was investigated. Busulfan, an anti-cancer drug widely used to treat chronic myelogenous leukemia was used as test drug while trypsin and lipase were used as model enzymes. The CD-MOFs were prepared by dissolving alkali metal salts and ?-cyclodextrin in water followed by vapor diffusion in varying solvents (methanol, ethanol, acetone and tetrahydrofuran) for several days. Crystals were activated via dichloromethane dispersion and in vacuo drying. Slow vapor diffusion with ethanol was found to give the highest yield and fastest crystallization time among all the solvents used. CD-MOFs synthesized using ethanol were characterized to be cubic crystals with sizes ranging from 1000-100m that are stable up to 250C. Loading of busulfan (%S) onto the CDMOFs and co-crystallization with trypsin (%N) were both successful as confirmed by elemental analysis. Loading studies of busulfan performed using 1H-NMR spectroscopy confirmed about 5 wt% loading in CD-MOFs.
format text
author PEREZ, YOMKIPPUR
author_facet PEREZ, YOMKIPPUR
author_sort PEREZ, YOMKIPPUR
title Cyclodextrin Metal-Organic Framework (CD-MOF) synthesis and its application in loading bio-active molecules
title_short Cyclodextrin Metal-Organic Framework (CD-MOF) synthesis and its application in loading bio-active molecules
title_full Cyclodextrin Metal-Organic Framework (CD-MOF) synthesis and its application in loading bio-active molecules
title_fullStr Cyclodextrin Metal-Organic Framework (CD-MOF) synthesis and its application in loading bio-active molecules
title_full_unstemmed Cyclodextrin Metal-Organic Framework (CD-MOF) synthesis and its application in loading bio-active molecules
title_sort cyclodextrin metal-organic framework (cd-mof) synthesis and its application in loading bio-active molecules
publisher Archīum Ateneo
publishDate 2017
url https://archium.ateneo.edu/theses-dissertations/125
http://rizalls.lib.admu.edu.ph/#section=resource&resourceid=1193570974&currentIndex=0&view=fullDetailsDetailsTab
_version_ 1712577792294518784