A preliminary study on the antitumor potential of Azadirachta indica (Neem Tree) leaves and Alstonia scholaris (Devil's tree) bark extact on skin tumor induced albino mice (mus musculus).
Tumor inhibition efficacy of two medicinal plants which were derived from the extracts of Neem tree (Azadirachta indica) leaves and Devil‘s tree (Alstonia scholaris) bark was investigated on Benzene initiated, Chlorofom and Cyclohexanone promoted skin tumor development in 30 day old male albino...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
2010
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| Subjects: | |
| Online Access: | http://thesis.dlsud.edu.ph/896/7/BasulPanuncio%20...%20-%20SkinTumor.pdf http://thesis.dlsud.edu.ph/896/ |
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| Institution: | De La Salle University |
| Summary: | Tumor inhibition efficacy of two medicinal plants which were derived from the
extracts of Neem tree (Azadirachta indica) leaves and Devil‘s tree (Alstonia
scholaris) bark was investigated on Benzene initiated, Chlorofom and
Cyclohexanone promoted skin tumor development in 30 day old male albino
mice. Eight treatments were utilized, including the negative normal group where
no chemicals or extracts were applied to the mice skin and positive control group
where the initiator and promoters were applied at the maximum tolerated dose of
the mice using the brushing method. After twenty weeks of experimentation the
mice were sacrificed and the desired portion of the dorsal skin was collected. The
collected skin was subjected to histopathological analysis based on set parameters
for the incidence of tumor formation. Significant difference on the incidence of
skin tumor treated with various concentrations of Neem tree leaves and Devil‘s
tree bark extracts were observed. Among the two plant extracts Neem tree leaves
exhibited the most inhibition as confirmed by histopathological analysis and
Kruskal - Wallis H Test statistical tool method. The factor that is responsible for
the inhibition of tumor growth is that medicinal plants have a characteristic of
containing chemical components known to have an anti-tumor potential. |
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