Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines, and chemokines

• Main Authors: Ivan, Fransiskus X., Rajapakse, Jagath C., Welsch, Roy E., Rozen, Steve G., Narasaraju, T., Xiong, Gordon M., Engelward, Bevin P., Chow, Vincent T. K.
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Computer science and engineering
• Online Access: https://hdl.handle.net/10356/100019; http://hdl.handle.net/10220/16283
• Institution: Nanyang Technological University

Investigating the relationships between critical influenza viral mutations contributing to increased virulence and host expression factors will shed light on the process of severe pathogenesis from the systems biology perspective. We previously generated a mouse-adapted, highly virulent influenza (H...