Mechanosensing of DNA bending in a single specific protein-DNA complex

• Main Authors: Le, Shimin, Chen, Hu, Cong, Peiwen, Lin, Jie, Dröge, Peter, Yan, Jie
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/100025; http://hdl.handle.net/10220/18638
• Institution: Nanyang Technological University

Many crucial biological processes are regulated by mechanical stimuli. Here, we report new findings that pico-Newton forces can drastically affect the stability of the site-specific DNA binding of a single transcription factor, the E. coli integration host factor (IHF), by stretching a short ~150 nm...