Proteomics-related biomarkers for HBV-associated hepatocellular carcinoma : current status and future prospects

HBV infection is the major cause of the development of hepatocellular carcinoma (HCC). HCC is one of the most common malignancies in the world. The morbidity rate associated with HCC is mainly linked to late diagnosis. Thus, it is very important to discover prognostic factors that can act as biomark...

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Main Authors: Sadrolodabaee, Laleh, Feng, Huixing, Zhang, Jianhua, Tan, Jane YL., Chen, William Wei Ning
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/100039
http://hdl.handle.net/10220/16286
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1000392020-03-07T11:35:20Z Proteomics-related biomarkers for HBV-associated hepatocellular carcinoma : current status and future prospects Sadrolodabaee, Laleh Feng, Huixing Zhang, Jianhua Tan, Jane YL. Chen, William Wei Ning School of Chemical and Biomedical Engineering HBV infection is the major cause of the development of hepatocellular carcinoma (HCC). HCC is one of the most common malignancies in the world. The morbidity rate associated with HCC is mainly linked to late diagnosis. Thus, it is very important to discover prognostic factors that can act as biomarkers for preventing HCC development, and those that can act as therapeutic targets. Proteomics analysis has been applied to identify biomarkers from clinical HCC samples. In addition, the cell-based HBV replication and viral protein overexpression system, which provides a model of the cell at an early stage of viral infection, was also used to identify biomarkers. The proteins identified at this stage may be relevant to HBV-associated HCC prognosis. In this review, we discuss the current status of proteomics analysis in the discovery of cellular proteins and prognostic HCC biomarkers, with a special focus on cell metastasis and angiogenesis. 2013-10-04T07:39:28Z 2019-12-06T20:15:36Z 2013-10-04T07:39:28Z 2019-12-06T20:15:36Z 2012 2012 Journal Article Feng, H., Zhang, J., Tan, J. YL., Sadrolodabaee, L., & Chen, W. N. W. (2012). Proteomics-related biomarkers for HBV-associated hepatocellular carcinoma : current status and future prospects. Future virology, 7(2), 161-171. https://hdl.handle.net/10356/100039 http://hdl.handle.net/10220/16286 10.2217/fvl.11.148 en Future virology
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
description HBV infection is the major cause of the development of hepatocellular carcinoma (HCC). HCC is one of the most common malignancies in the world. The morbidity rate associated with HCC is mainly linked to late diagnosis. Thus, it is very important to discover prognostic factors that can act as biomarkers for preventing HCC development, and those that can act as therapeutic targets. Proteomics analysis has been applied to identify biomarkers from clinical HCC samples. In addition, the cell-based HBV replication and viral protein overexpression system, which provides a model of the cell at an early stage of viral infection, was also used to identify biomarkers. The proteins identified at this stage may be relevant to HBV-associated HCC prognosis. In this review, we discuss the current status of proteomics analysis in the discovery of cellular proteins and prognostic HCC biomarkers, with a special focus on cell metastasis and angiogenesis.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Sadrolodabaee, Laleh
Feng, Huixing
Zhang, Jianhua
Tan, Jane YL.
Chen, William Wei Ning
format Article
author Sadrolodabaee, Laleh
Feng, Huixing
Zhang, Jianhua
Tan, Jane YL.
Chen, William Wei Ning
spellingShingle Sadrolodabaee, Laleh
Feng, Huixing
Zhang, Jianhua
Tan, Jane YL.
Chen, William Wei Ning
Proteomics-related biomarkers for HBV-associated hepatocellular carcinoma : current status and future prospects
author_sort Sadrolodabaee, Laleh
title Proteomics-related biomarkers for HBV-associated hepatocellular carcinoma : current status and future prospects
title_short Proteomics-related biomarkers for HBV-associated hepatocellular carcinoma : current status and future prospects
title_full Proteomics-related biomarkers for HBV-associated hepatocellular carcinoma : current status and future prospects
title_fullStr Proteomics-related biomarkers for HBV-associated hepatocellular carcinoma : current status and future prospects
title_full_unstemmed Proteomics-related biomarkers for HBV-associated hepatocellular carcinoma : current status and future prospects
title_sort proteomics-related biomarkers for hbv-associated hepatocellular carcinoma : current status and future prospects
publishDate 2013
url https://hdl.handle.net/10356/100039
http://hdl.handle.net/10220/16286
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