A P-loop mutation in Gα subunits prevents transition to the active state : implications for G-protein signaling in fungal pathogenesis

• Main Authors: Siderovski, David P., Bosch, Dustin E., Willard, Francis S., Kimple, Adam J., Willard, Melinda D., Naqvi, Naweed Issak., Ramanujam, Ravikrishna.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/100154; http://hdl.handle.net/10220/10955
• Institution: Nanyang Technological University

Heterotrimeric G-proteins are molecular switches integral to a panoply of different physiological responses that many organisms make to environmental cues. The switch from inactive to active Gαβγ heterotrimer relies on nucleotide cycling by the Gα subunit: exchange of GTP for GDP activates Gα, where...