Combining parasite lactate dehydrogenase-based and histidine-rich protein 2-based rapid tests to improve specificity for diagnosis of malaria due to plasmodium knowlesi and other plasmodium species in Sabah, Malaysia

• Main Authors: Grigg, Matthew J., William, Timothy, Barber, Bridget E., Parameswaran, Uma, Bird, Elspeth, Piera, Kim, Aziz, Ammar, Dhanaraj, Prabakaran, Yeo, Tsin Wen, Anstey, Nicholas M.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/100222; http://hdl.handle.net/10220/25726
• Institution: Nanyang Technological University

Plasmodium knowlesi causes severe and fatal malaria in Malaysia. Microscopic misdiagnosis is common and may delay appropriate treatment. P. knowlesi can cross-react with “species-specific” parasite lactate dehydrogenase (pLDH) monoclonal antibodies used in rapid diagnostic tests (RDTs) to detect P....