In vivo splenic clearance correlates with In vitro deformability of red blood cells from plasmodium yoelii-infected mice

• Main Authors: Huang, Sha, Amaladoss, Anburaj, Liu, Min, Chen, Huichao, Zhang, Rou, Preiser, Peter R., Dao, Ming, Han, Jongyoon
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology
• Online Access: https://hdl.handle.net/10356/100385; http://hdl.handle.net/10220/25731
• Institution: Nanyang Technological University

Recent experimental and clinical studies suggest a crucial role of mechanical splenic filtration in the host's defense against malaria parasites. Subtle changes in red blood cell (RBC) deformability, caused by infection or drug treatment, could influence the pathophysiological outcome. However,...