The N-terminal zinc binding domain of ClpX is a dimerization domain that modulates the chaperone function

Clp ATPases are unique chaperones that promote protein unfolding and subsequent degradation by proteases. The mechanism by which this occurs is poorly understood. Here we demonstrate that the N-terminal domain of ClpX is a C4-type zinc binding domain (ZBD) involved in substrate recognition. ZBD...

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Bibliographic Details
Main Authors: Wojtyra, U. A., Houry, Walid A., Thibault, Guillaume, Tuite, Ashleigh
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2013
Subjects:
Online Access:https://hdl.handle.net/10356/100398
http://hdl.handle.net/10220/17900
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Institution: Nanyang Technological University
Language: English