Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis

• Main Authors: Su, I-hsin, Talukder, Asoke K., Nojima, Takuya, Doglioni, Claudio, Kitamura, Daisuke, Toellner, Kai-M, Casola, Stefano, Caganova, Marieta, Carrisi, Chiara, Varano, Gabriele, Mainoldi, Federica, Zanardi, Federica, Germain, Pierre-Luc, George, Laura, Alberghini, Federica, Ferrarini, Luca, Ponzoni, Maurilio, Testa, Giuseppe
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/100438; http://hdl.handle.net/10220/17889
• Institution: Nanyang Technological University

Protection against deadly pathogens requires the production of high-affinity antibodies by B cells, which are generated in germinal centers (GCs). Alteration of the GC developmental program is common in many B cell malignancies. Identification of regulators of the GC response is crucial to develop t...