An improved classification of G-protein-coupled receptors using sequence-derived features

• Main Authors: Peng, Zhen-Ling, Yang, Jian-Yi, Chen, Xin
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: Mathematical Sciences
• Online Access: https://hdl.handle.net/10356/100530; http://hdl.handle.net/10220/17875
• Institution: Nanyang Technological University

Background: G-protein-coupled receptors (GPCRs) play a key role in diverse physiological processes and are the targets of almost two-thirds of the marketed drugs. The 3 D structures of GPCRs are largely unavailable; however, a large number of GPCR primary sequences are known. To facilitate the ide...