A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets

• Main Authors: Tao, Jiong, Tan, Iain Beehuat, Deng, Niantao, Goh, Liang-Kee, Wang, Hannah, Das, Kakoli, Zhang, Shenli, Lee, Minghui, Wu, Jeanie, Lim, Kiat Hon, Lei, Zhengdeng, Goh, Glenn, Lim, Qing-Yan, Tan, Angie Lay-Keng, Poh, Dianne Yu Sin, Riahi, Sudep, Bell, Sandra, Linnartz, Ronald, Zhu, Feng, Yeoh, Khay Guan, Toh, Han Chong, Yong, Wei Peng, Cheong, Hyun Cheol, Rha, Sun Young, Boussioutas, Alex, Grabsch, Heike, Tan, Patrick, Shi, Michael M., Rozen, Steve G.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/100653; http://hdl.handle.net/10220/16299
• Institution: Nanyang Technological University

Objective Gastric cancer is a major gastrointestinal malignancy for which targeted therapies are emerging as treatment options. This study sought to identify the most prevalent molecular targets in gastric cancer and to elucidate systematic patterns of exclusivity and co-occurrence among these targe...