The 2012 dengue outbreak in Madeira: exploring the origins
In 2012, Madeira reported its first major outbreak of dengue. To identify the origin of the imported dengue virus, we investigated the interconnectivity via air travel between dengue-endemic countries and Madeira, and compared available sequences against GenBank. There were 22,948 air travellers to...
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sg-ntu-dr.10356-1007452020-11-01T05:15:54Z The 2012 dengue outbreak in Madeira: exploring the origins Wilder-Smith, Annelies Quam, M Sessions, O Rocklov, J Liu-Helmersson, J Franco, L Khan, K Lee Kong Chian School of Medicine (LKCMedicine) DRNTU::Science::Medicine In 2012, Madeira reported its first major outbreak of dengue. To identify the origin of the imported dengue virus, we investigated the interconnectivity via air travel between dengue-endemic countries and Madeira, and compared available sequences against GenBank. There were 22,948 air travellers to Madeira in 2012, originating from twenty-nine dengue-endemic countries; 89.6% of these international travellers originated from Venezuela and Brazil. We developed an importation index that takes into account both travel volume and the extent of dengue incidence in the country of origin. Venezuela and Brazil had by far the highest importation indices compared with all other dengue-endemic countries. The importation index for Venezuela was twice as high as that for Brazil. When taking into account seasonality in the months preceding the onset of the Madeira outbreak, this index was even seven times higher for Venezuela than for Brazil during this time. Dengue sequencing shows that the virus responsible for the Madeira outbreak was most closely related to viruses circulating in Venezuela, Brazil and Columbia. Applying the importation index, Venezuela was identified as the most likely origin of importation of dengue virus via travellers to Madeira. We propose that the importation index is a new additional tool that can help to identify and anticipate the most probable country of origin for importation of dengue into currently non-endemic countries. Published version 2014-06-12T02:31:08Z 2019-12-06T20:27:32Z 2014-06-12T02:31:08Z 2019-12-06T20:27:32Z 2014 2014 Journal Article Wilder-Smith, A., Quam, M., Sessions, O., Rocklov, J., Liu-Helmersson, J., Franco, L. et al. (2014). The 2012 dengue outbreak in Madeira: exploring the origins. Eurosurveillance, 19(8), 20718-. 1560-7917 https://hdl.handle.net/10356/100745 http://hdl.handle.net/10220/19685 http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20718 en Eurosurveillance © 2014 Eurosurveillance. This paper was published in Eurosurveillance and is made available as an electronic reprint (preprint) with permission of Eurosurveillance. The paper can be found at the following official URL: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20718. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. application/pdf |
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DRNTU::Science::Medicine Wilder-Smith, Annelies Quam, M Sessions, O Rocklov, J Liu-Helmersson, J Franco, L Khan, K The 2012 dengue outbreak in Madeira: exploring the origins |
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In 2012, Madeira reported its first major outbreak of dengue. To identify the origin of the imported dengue virus, we investigated the interconnectivity via air travel between dengue-endemic countries and Madeira, and compared available sequences against GenBank. There were 22,948 air travellers to Madeira in 2012, originating from twenty-nine dengue-endemic countries; 89.6% of these international travellers originated from Venezuela and Brazil. We developed an importation index that takes into account both travel volume and the extent of dengue incidence in the country of origin. Venezuela and Brazil had by far the highest importation indices compared with all other dengue-endemic countries. The importation index for Venezuela was twice as high as that for Brazil. When taking into account seasonality in the months preceding the onset of the Madeira outbreak, this index was even seven times higher for Venezuela than for Brazil during this time. Dengue sequencing shows that the virus responsible for the Madeira outbreak was most closely related to viruses circulating in Venezuela, Brazil and Columbia. Applying the importation index, Venezuela was identified as the most likely origin of importation of dengue virus via travellers to Madeira. We propose that the importation index is a new additional tool that can help to identify and anticipate the most probable country of origin for importation of dengue into currently non-endemic countries. |
author2 |
Lee Kong Chian School of Medicine (LKCMedicine) |
author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Wilder-Smith, Annelies Quam, M Sessions, O Rocklov, J Liu-Helmersson, J Franco, L Khan, K |
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Article |
author |
Wilder-Smith, Annelies Quam, M Sessions, O Rocklov, J Liu-Helmersson, J Franco, L Khan, K |
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Wilder-Smith, Annelies |
title |
The 2012 dengue outbreak in Madeira: exploring the origins |
title_short |
The 2012 dengue outbreak in Madeira: exploring the origins |
title_full |
The 2012 dengue outbreak in Madeira: exploring the origins |
title_fullStr |
The 2012 dengue outbreak in Madeira: exploring the origins |
title_full_unstemmed |
The 2012 dengue outbreak in Madeira: exploring the origins |
title_sort |
2012 dengue outbreak in madeira: exploring the origins |
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2014 |
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https://hdl.handle.net/10356/100745 http://hdl.handle.net/10220/19685 http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20718 |
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