Promoter sequence determines the relationship between expression level and noise

• Main Authors: Carey, Lucas B., van Dijk, David., Sloot, Peter M. A., Kaandorp, Jaap A., Segal, Eran.
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Computer science and engineering::Computer applications::Life and medical sciences
• Online Access: https://hdl.handle.net/10356/100847; http://hdl.handle.net/10220/9866
• Institution: Nanyang Technological University

The ability of cells to accurately control gene expression levels in response to extracellular cues is limited by the inherently stochastic nature of transcriptional regulation. A change in transcription factor (TF) activity results in changes in the expression of its targets, but the way in which c...