A mathematical model for fluid shear-sensitive 3D tissue construct development

• Main Authors: Liu, Dan, Chua, Chee Kai, Leong, Kah Fai
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Mechanical engineering
• Online Access: https://hdl.handle.net/10356/101018; http://hdl.handle.net/10220/16784
• Institution: Nanyang Technological University

This research studies dynamic culture for 3D tissue construct development with computational fluid dynamics. It proposes a mathematical model to evaluate the impact of flow rates and flow shear stress on cell growth in 3D constructs under perfusion. The modeling results show that dynamic flow, even...