Multi-channel deep tissue flowmetry based on temporal diffuse speckle contrast analysis

• Main Authors: Bi, Renzhe, Dong, Jing, Lee, Kijoon
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Bioengineering
• Online Access: https://hdl.handle.net/10356/101033; http://hdl.handle.net/10220/18296
• Institution: Nanyang Technological University

Recently, diffuse speckle contrast analysis (DSCA) was introduced as a competent modality for deep tissue blood flow measurement, where the speckle contrast is calculated over spatial domain on the CCD image of diffuse reflectance. In this paper, we introduce time-domain DSCA where temporal statistics are used for speckle contrast calculation and results in the same deep tissue flow measurement. This new modality is especially suitable for multi-channel real-time flowmetry, and we demonstrate its performance on human arm during cuff occlusion test. Independent component analysis (ICA) study on multi-channel data shows promising results about underlying physiology.