Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice

• Main Authors: Kline, Kimberly A., Guiton, Pascale S., Cusumano, Corinne K., Dodson, Karen W., Han, Zhenfu., Janetka, James W., Henderson, Jeffrey P., Caparon, Michael G., Hultgren, Scott J.
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/101172; http://hdl.handle.net/10220/10994
• Institution: Nanyang Technological University

Catheter-associated urinary tract infections (CAUTIs) constitute the majority of nosocomial urinary tract infections (UTIs) and pose significant clinical challenges. These infections are polymicrobial in nature and are often associated with multidrug-resistant pathogens, including uropathogenic Esch...