Immobilization of antibacterial dihydropyrrol-2-ones on functional polymer supports to prevent bacterial infections in vivo

• Main Authors: Rice, Scott A., Kumar, Naresh, Ho, Kitty Ka Kit, Cole, Nerida, Chen, Renxun, Willcox, Mark D. P.
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/101252; http://hdl.handle.net/10220/10995
• Institution: Nanyang Technological University

Antibiotic-resistant Staphylococcus aureus is of great concern, as it causes a wide range of life-threatening infections. The current study demonstrates that dihydropyrrolone (DHP)-coated polyacrylamide substrates are effective in reducing the number of culturable clinical isolates of S. aureus in vitro in a dose-dependent manner and are able to reduce the pathogenic potential of staphylococcal infection in a subcutaneous infection model. Covalently bound DHPs therefore show great potential for use as an antimicrobial strategy in device-related applications.