ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters

• Main Authors: Huang, Royston-Luke, Teo, Ziqiang, Chong, Han Chung, Zhu, Pengcheng, Tan, Ming Jie, Tan, Chek Kun, Lam, Ivan Chee Ren, Tan, Nguan Soon, Sng, Ming Keat, Leong, David Tai Wei, Tan, Suet Mien, Kersten, Sander, Ding, Jeak Ling, Li, Hoi-Yeung
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/101257; http://hdl.handle.net/10220/7264
• Institution: Nanyang Technological University

Vascular disruption induced by interactions between tumor-secreted permeability factors and adhesive proteins on endothelial cells facilitates metastasis. The role of tumor-secreted angiopoietin-like 4 (cANGPTL4) in vascular leakiness and metastasis is controversial due to the lack of understanding...