Analysis of epigenetic factors in mouse embryonic neural stem cells exposed to hyperglycemia

• Main Authors: Shyamasundar, Sukanya, Bay, Boon Huat, Tay, Samuel Sam Wah, Kumar, S. Dinesh, Rangasamy, Danny, Dheen, S. Thameem, Jadhav, Shweta P.
• Other Authors: Pant, Aditya Bhushan
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/101283; http://hdl.handle.net/10220/18417
• Institution: Nanyang Technological University

Background: Maternal diabetes alters gene expression leading to neural tube defects (NTDs) in the developing brain. The mechanistic pathways that deregulate the gene expression remain unknown. It is hypothesized that exposure of neural stem cells (NSCs) to high glucose/hyperglycemia results in act...