Weak affinity chromatography for evaluation of stereoisomers in early drug discovery

• المؤلفون الرئيسيون: Duong-Thi, M.-D., Bergstrom, M., Fex, T., Svensson, S., Ohlson, S., Isaksson, R.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Science::Biological sciences::Microbiology
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/101288; http://hdl.handle.net/10220/16729

In early drug discovery (e.g., in fragment screening), recognition of stereoisomeric structures is valuable and guides medicinal chemists to focus only on useful configurations. In this work, we concurrently screened mixtures of stereoisomers and estimated their affinities to a protein target (throm...