Weak affinity chromatography for evaluation of stereoisomers in early drug discovery

• Main Authors: Duong-Thi, M.-D., Bergstrom, M., Fex, T., Svensson, S., Ohlson, S., Isaksson, R.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Microbiology
• Online Access: https://hdl.handle.net/10356/101288; http://hdl.handle.net/10220/16729
• Institution: Nanyang Technological University

In early drug discovery (e.g., in fragment screening), recognition of stereoisomeric structures is valuable and guides medicinal chemists to focus only on useful configurations. In this work, we concurrently screened mixtures of stereoisomers and estimated their affinities to a protein target (throm...