Mammalian Mon2/Ysl2 regulates endosome-to-Golgi trafficking but possesses no guanine nucleotide exchange activity toward Arl1 GTPase

• Main Authors: Zhou, Y., Mahajan, Divyanshu, Boh, Boon Kim, Chen, Li, Cornvik, Tobias Carl, Hong, Wanjin, Lu, Lei
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/101310; http://hdl.handle.net/10220/18405
• Institution: Nanyang Technological University

Arl1 is a member of Arf family small GTPases that is essential for the organization and function of Golgi complex. Mon2/Ysl2, which shares significant homology with Sec7 family Arf guanine nucleotide exchange factors, was poorly characterized in mammalian cells. Here, we report the first in depth ch...