Phenotyping of an in vitro model of ischemic penumbra by iTRAQ-based shotgun quantitative proteomics

• Main Authors: Tam, James P., Datta, Arnab, Park, Jung Eun, Li, Xin, Zhang, Huoming, Ho, Zhi Shan, Heese, Klaus, Lim, Sai Kiang, Sze, Siu Kwan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/101333; http://hdl.handle.net/10220/18371
• Institution: Nanyang Technological University

Cerebral ischemia is a major cause of death and long-term disability worldwide. Ischemic penumbra, the electrically silent but metabolically viable perifocal brain tissue, is the target for the much elusive stroke therapy. To characterize the molecular events of the dynamic penumbra, we applied an i...