Quantitative clinical proteomic study of autopsied human infarcted brain specimens to elucidate the deregulated pathways in ischemic stroke pathology

• Main Authors: Datta, Arnab, Akatsu, Hiroyasu, Heese, Klaus, Sze, Siu Kwan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology
• Online Access: https://hdl.handle.net/10356/101402; http://hdl.handle.net/10220/18364
• Institution: Nanyang Technological University

Ischemic stroke, still lacking an effective neuroprotective therapy is the third leading cause of global mortality and morbidity. Here, we have applied an 8-plex iTRAQ-based 2D-LC–MS/MS strategy to study the commonly regulated infarct proteome from three different brain regions (putamen, thalamus an...