Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1
Translation termination in eukaryotes is catalyzed by two release factors eRF1 and eRF3 in a cooperative manner. The precise mechanism of stop codon discrimination by eRF1 remains obscure, hindering drug development targeting aberrations at translation termination. By solving the solution structures...
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| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/101527 http://hdl.handle.net/10220/18690 |
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| Institution: | Nanyang Technological University |
| Language: | English |