Cell depletion in mice that express diphtheria toxin receptor under the control of SiglecH encompasses more than plasmacytoid dendritic cells

• Main Authors: Swiecki, Melissa, Wang, Yaming, Riboldi, Elena, Kim, Alfred H. J., Dzutsev, Amiran, Gilfillan, Susan, Vermi, William, Ruedl, Christiane, Trinchieri, Giorgio, Colonna, Marco
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Microbiology
• Online Access: https://hdl.handle.net/10356/101579; http://hdl.handle.net/10220/19729
• Institution: Nanyang Technological University

Plasmacytoid dendritic cells (pDC) produce IFN-I in response to viruses and are routinely identified in mice by SiglecH expression. SiglecH is a sialic acid–binding Ig-like lectin that has an immunomodulatory role during viral infections. In this study, we evaluated the impact of SiglecH deficiency...