Conformational antibody binding to a native, cell-free expressed GPCR in block copolymer membranes

• Main Authors: De Hoog, Hans-Peter M., Lin JieRong, Esther M., Banerjee, Sourabh, Décaillot, Fabien M., Nallani, Madhavan
• Other Authors: Karnik, Sadashiva
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Engineering::Materials::Biomaterials
• Online Access: https://hdl.handle.net/10356/101602; http://hdl.handle.net/10220/24190
• Institution: Nanyang Technological University

G-protein coupled receptors (GPCRs) play a key role in physiological processes and are attractive drug targets. Their biophysical characterization is, however, highly challenging because of their innate instability outside a stabilizing membrane and the difficulty of finding a suitable expression sy...