Evolutionarily ancient association of the FoxJ1 transcription factor with the motile ciliogenic program

• Main Authors: Vij, Shubha, Eitel, Michael, Ho, Hao Kee, Babu, Deepak, Narasimhan, Vijayashankaranarayanan, Tiku, Varnesh, Westbrook, Jody, Schierwater, Bernd, Roy, Sudipto, Rink, Jochen C.
• Other Authors: Malik, Harmit S.
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/101613; http://hdl.handle.net/10220/18689
• Institution: Nanyang Technological University

It is generally believed that the last eukaryotic common ancestor (LECA) was a unicellular organism with motile cilia. In the vertebrates, the winged-helix transcription factor FoxJ1 functions as the master regulator of motile cilia biogenesis. Despite the antiquity of cilia, their highly conserved...