The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain Fatty acids

• Main Authors: Reddy, Janardan K., Ding, Jun, Loizides-Mangold, Ursula, Rando, Gianpaolo, Zoete, Vincent, Michielin, Olivier, Wahli, Walter, Riezman, Howard, Thorens, Bernard
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/101676; http://hdl.handle.net/10220/18745
• Institution: Nanyang Technological University

Specific metabolic pathways are activated by different nutrients to adapt the organism to available resources. Although essential, these mechanisms are incompletely defined. Here, we report that medium-chain fatty acids contained in coconut oil, a major source of dietary fat, induce the liver ω-oxid...