CD163 and IgG codefend against cytotoxic hemoglobin via autocrine and paracrine mechanisms

• Main Authors: Subramanian, Karthik, Du, Ruijuan, Tan, Nguan Soon, Ho, Bow, Ding, Jeak Ling
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/101704; http://hdl.handle.net/10220/19771
• Institution: Nanyang Technological University

Lysis of RBCs during numerous clinical settings such as severe hemolytic anemia, infection, tissue injury, or blood transfusion releases the endogenous damage-associated molecular pattern, hemoglobin (Hb), into the plasma. The redox-reactive Hb generates cytotoxic reactive oxygen species, disrupting...