Apelin inhibits adipogenesis and lipolysis through distint molecular pathways

Apelin is an adipokine secreted by adipocytes. Co-expression of apelin and apelin receptor (APJ) in adipocytes implies the autocrine regulations of apelin on adipocyte functions through yet unknown molecular mechanisms. In the present study, we provide evidence that apelin, through its interaction w...

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Main Authors: Than, Aung, Cheng, Yiqi, Foh, Li-Chern, Leow, Melvin Khee-Shing, Lim, Su Chi, Chuah, Yon Jin, Kang, Yuejun, Chen, Peng
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/101915
http://hdl.handle.net/10220/11157
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1019152020-03-07T11:40:23Z Apelin inhibits adipogenesis and lipolysis through distint molecular pathways Than, Aung Cheng, Yiqi Foh, Li-Chern Leow, Melvin Khee-Shing Lim, Su Chi Chuah, Yon Jin Kang, Yuejun Chen, Peng School of Chemical and Biomedical Engineering Apelin is an adipokine secreted by adipocytes. Co-expression of apelin and apelin receptor (APJ) in adipocytes implies the autocrine regulations of apelin on adipocyte functions through yet unknown molecular mechanisms. In the present study, we provide evidence that apelin, through its interaction with APJ receptor, inhibits adipogenesis of pre-adipocytes and lipolysis in mature adipocytes. The detailed molecular pathways underlying apelin signaling is proposed based on our experimental observations. Specifically, we show that apelin suppresses adipogenesis through MAPK kinase/ERK dependent pathways. And by preventing lipid droplet fragmentation, apelin inhibits basal lipolysis through AMP kinase dependent enhancement of perilipin expression and inhibits hormone-stimulated acute lipolysis through decreasing perilipin phosphorylation. Apelin induced decrease of free fatty acid release can be attributed to its dual inhibition on adipogenesis and lipolysis. This study suggests that the autocrine signaling of apelin may serve as a novel therapeutic target for obesity and other metabolic disorders. 2013-07-11T02:11:01Z 2019-12-06T20:46:36Z 2013-07-11T02:11:01Z 2019-12-06T20:46:36Z 2012 2012 Journal Article Than, A., Cheng, Y., Foh, L.-C., Leow, M. K.-S., Lim, S. C., Chuah, Y. J., et al. (2012). Apelin inhibits adipogenesis and lipolysis through distint molecular pathways. Molecular and Cellular Endocrinology, 362(1-2), 227-241. https://hdl.handle.net/10356/101915 http://hdl.handle.net/10220/11157 10.1016/j.mce.2012.07.002 en Molecular and cellular endocrinology © 2012 Elsevier Ireland Ltd.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
description Apelin is an adipokine secreted by adipocytes. Co-expression of apelin and apelin receptor (APJ) in adipocytes implies the autocrine regulations of apelin on adipocyte functions through yet unknown molecular mechanisms. In the present study, we provide evidence that apelin, through its interaction with APJ receptor, inhibits adipogenesis of pre-adipocytes and lipolysis in mature adipocytes. The detailed molecular pathways underlying apelin signaling is proposed based on our experimental observations. Specifically, we show that apelin suppresses adipogenesis through MAPK kinase/ERK dependent pathways. And by preventing lipid droplet fragmentation, apelin inhibits basal lipolysis through AMP kinase dependent enhancement of perilipin expression and inhibits hormone-stimulated acute lipolysis through decreasing perilipin phosphorylation. Apelin induced decrease of free fatty acid release can be attributed to its dual inhibition on adipogenesis and lipolysis. This study suggests that the autocrine signaling of apelin may serve as a novel therapeutic target for obesity and other metabolic disorders.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Than, Aung
Cheng, Yiqi
Foh, Li-Chern
Leow, Melvin Khee-Shing
Lim, Su Chi
Chuah, Yon Jin
Kang, Yuejun
Chen, Peng
format Article
author Than, Aung
Cheng, Yiqi
Foh, Li-Chern
Leow, Melvin Khee-Shing
Lim, Su Chi
Chuah, Yon Jin
Kang, Yuejun
Chen, Peng
spellingShingle Than, Aung
Cheng, Yiqi
Foh, Li-Chern
Leow, Melvin Khee-Shing
Lim, Su Chi
Chuah, Yon Jin
Kang, Yuejun
Chen, Peng
Apelin inhibits adipogenesis and lipolysis through distint molecular pathways
author_sort Than, Aung
title Apelin inhibits adipogenesis and lipolysis through distint molecular pathways
title_short Apelin inhibits adipogenesis and lipolysis through distint molecular pathways
title_full Apelin inhibits adipogenesis and lipolysis through distint molecular pathways
title_fullStr Apelin inhibits adipogenesis and lipolysis through distint molecular pathways
title_full_unstemmed Apelin inhibits adipogenesis and lipolysis through distint molecular pathways
title_sort apelin inhibits adipogenesis and lipolysis through distint molecular pathways
publishDate 2013
url https://hdl.handle.net/10356/101915
http://hdl.handle.net/10220/11157
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