Mapping the structural and dynamical features of multiple p53 DNA binding domains : insights into loop 1 intrinsic dynamics
The transcription factor p53 regulates cellular integrity in response to stress. p53 is mutated in more than half of cancerous cells, with a majority of the mutations localized to the DNA binding domain (DBD). In order to map the structural and dynamical features of the DBD, we carried out multiple...
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| Main Authors: | , , |
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| 格式: | Article |
| 語言: | English |
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2014
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| 在線閱讀: | https://hdl.handle.net/10356/101936 http://hdl.handle.net/10220/18829 |
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