Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket

• Main Authors: Siau, Jia Wei, Kannan, Srinivasaraghavan, Ouaray, Zohra, Kwoh, Chee Keong, Ghadessy, Farid, Pradhan, Mohan Rajan, Nguyen, Minh N., Lane, David P., Verma, Chandra Shekhar
• Other Authors: School of Computer Science and Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: DNA Binding Domain; P53; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/105824; http://hdl.handle.net/10220/48748
• Institution: Nanyang Technological University

The DNA binding domain (DBD) of the tumor suppressor p53 is the site of several oncogenic mutations. A subset of these mutations lowers the unfolding temperature of the DBD. Unfolding leads to the exposure of a hydrophobic β-strand and nucleates aggregation which results in pathologies through loss...