Integration of regulatory networks by NKX3-1 promotes androgen-dependent prostate cancer survival

• Main Authors: Tan, Peck Yean, Chang, Cheng Wei, Chng, Kern Rei, Wansa, K. D. Senali Abayratna, Sung, Wing-Kin, Cheung, Edwin
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/102012; http://hdl.handle.net/10220/11164
• Institution: Nanyang Technological University

The NKX3-1 gene is a homeobox gene required for prostate tumor progression, but how it functions is unclear. Here, using chromatin immunoprecipitation coupled to massively parallel sequencing (ChIP-seq) we showed that NKX3-1 colocalizes with the androgen receptor (AR) across the prostate cancer geno...